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Asthma drug 'isn't working on children' and could be making their illness worse
- Doctors warn asthma drug salmeterol may not work on one in seven cases
- A genetic quirk may stop it working, but research suggests alternative improves symptoms
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Doctors have warned a popular asthma drug used by tens of thousands of children may not work
A popular asthma drug used by tens of thousands of children may not work – and could even be making their illness worse, doctors have warned.
They say a genetic quirk means salmeterol does not help in one in seven cases.
With research showing that an alternative, montelukast, improves symptoms, they called on the Department of Health to provide new guidance.
Possibilities include giving asthmatic youngsters a £15 genetic test to work out the best treatment for them.
Somnath Mukhopadhyay, of Brighton and Sussex Medical School, said: ‘A common medication is not working in a significant proportion of the population.’
He said that when symptoms don't improve doctors often blame the mother for not giving the salmeterol properly, rather than concluding the drug isn’t working.
He said: ‘I think the time has come to move forward and be able to provide some clinical guidance to the parents.’
Treatment of asthma follows a series of steps, with a new drug being added to the package if the previous combination doesn’t work.
Children are typically first prescribed a drug to take to open up their airways during an attack. This often comes in a blue inhaler.
If that alone isn’t enough, they’ll be prescribed low-dose steroids, which may be in a brown inhaler.
If their asthma still isn’t under control, they’ll usually be given salmeterol, in a purple or green inhaler, and up to 100,000 British children are on all three drugs.
With a previous study suggesting that a particular gene stops some of the drugs form working in some children, Professor Mukhopadhyay and colleagues from Dundee University decided to compare salmeterol with another medicine called montelukast.
Sixty two children with the key gene took one of the drugs for a year and their health and quality of life was closely monitored.
Across the population as a whole, salmeterol works better than montelukast. But in these particular children, the reverse was true, the journal Clinical Science reports.
Those taking montelukast became less reliant on other drugs, their quality of life improved, they wheezed and coughed less and missed school less often.
In contrast, the health of those taking salmeterol did not improve and may even have got worse, said the professor.
Doctors have now urged the Department of Health to provide new guidance
Read more: http://www.dailymail.co.uk/health/article-2258769/Asthma-drug-isnt-working-children-making-illness-worse.html#ixzz2HZhfbVtn
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WARNING FROM RAEL: For those who don't use their intelligence at its
full capacity, the label "selected by RAEL" on some articles does not
mean that I agree with their content or support it. "Selected by RAEL"
means that I believe it is important for the people of this planet to
know about what people think or do, even when what they think or do is
completely stupid and against our philosophy. When I selected articles
in the past about stupid Christian fundamentalists in America praying
for rain, I am sure no Rael-Science reader was stupid enough to believe
that I was supporting praying to change the weather. So, when I select
articles which are in favor of drugs, anti-Semitic, anti-Jewish, racist,
revisionist, or inciting hatred against any group or religion, or any
other stupid article, it does not mean that I support them. It just
means that it is important for all human beings to know about them.
Common sense, which is usually very good among our readers, is good
enough to understand that. When, like in the recent articles on drug
decriminalization, it is necessary to make it clearer, I add a comment,
which in this case was very clear: I support decriminalizing all drugs,
as it is stupid to throw depressed and sad people (as only depressed and
sad people use drugs) in prison and ruin their life with a criminal
record. That does not mean that there is any change to the Message which
says clearly that we must not use any drug except for medical purposes.
The same applies to the freedom of expression which must be absolute.
That does not mean again of course that I agree with anti-Jews,
anti-Semites, racists of any kind or anti-Raelians. But by knowing your
enemies or the enemies of your values, you are better equipped to fight
them. With love and respect of course, and with the wonderful sentence
of the French philosopher Voltaire in mind: "I disapprove of what you
say, but I will defend to the death your right to say it".
WARNING FROM RAEL: For those who don't use their intelligence at its
full capacity, the label "selected by RAEL" on some articles does not
mean that I agree with their content or support it. "Selected by RAEL"
means that I believe it is important for the people of this planet to
know about what people think or do, even when what they think or do is
completely stupid and against our philosophy. When I selected articles
in the past about stupid Christian fundamentalists in America praying
for rain, I am sure no Rael-Science reader was stupid enough to believe
that I was supporting praying to change the weather. So, when I select
articles which are in favor of drugs, anti-Semitic, anti-Jewish, racist,
revisionist, or inciting hatred against any group or religion, or any
other stupid article, it does not mean that I support them. It just
means that it is important for all human beings to know about them.
Common sense, which is usually very good among our readers, is good
enough to understand that. When, like in the recent articles on drug
decriminalization, it is necessary to make it clearer, I add a comment,
which in this case was very clear: I support decriminalizing all drugs,
as it is stupid to throw depressed and sad people (as only depressed and
sad people use drugs) in prison and ruin their life with a criminal
record. That does not mean that there is any change to the Message which
says clearly that we must not use any drug except for medical purposes.
The same applies to the freedom of expression which must be absolute.
That does not mean again of course that I agree with anti-Jews,
anti-Semites, racists of any kind or anti-Raelians. But by knowing your
enemies or the enemies of your values, you are better equipped to fight
them. With love and respect of course, and with the wonderful sentence
of the French philosopher Voltaire in mind: "I disapprove of what you
say, but I will defend to the death your right to say it".
--
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"Ethics" is simply a last-gasp attempt by deist conservatives and
orthodox dogmatics to keep humanity in ignorance and obscurantism,
through the well tried fermentation of fear, the fear of science and
new technologies.
There is nothing glorious about what our ancestors call history,
it is simply a succession of mistakes, intolerances and violations.
On the contrary, let us embrace Science and the new technologies
unfettered, for it is these which will liberate mankind from the
myth of god, and free us from our age old fears, from disease,
death and the sweat of labour.
Rael
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