[rael-science] Epigenetics Underpins Homosexuality‏

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Source: http://www.genengnews.com/gen-news-highlights/epigenetics-underpins-homosexuality/81247763/

Epigenetics Underpins Homosexuality

From an evolutionary standpoint, homosexuality is a trait that would not be expected to develop and persist in the face of Darwinian natural selection, according to the scientists. Homosexuality is nevertheless common for men and women in most cultures. Previous studies have shown that homosexuality runs in families, leading most researchers to presume a genetic underpinning of sexual preference. However, the scientists continue, no major gene for homosexuality has been found despite numerous studies searching for a genetic connection.
In the current study, researchers from the Working Group on Intragenomic Conflict at the National Institute for Mathematical and Biological Synthesis (NIMBioS) integrated evolutionary theory with recent advances in the molecular regulation of gene expression and androgen-dependent sexual development to produce a biological and mathematical model that delineates the role of epigenetics in homosexuality. Epi-marks constitute an extra layer of information attached to our genes' backbones that regulates their expression. While genes hold the instructions, epi-marks direct how those instructions are carried out, i.e., when, where, and how much a gene is expressed during development. Epi-marks are usually produced each generation, but recent evidence demonstrates that they sometimes carryover between generations and thus can contribute to similarity among relatives, resembling the effect of shared genes.
Sex-specific epi-marks produced in early fetal development protect each sex from the substantial natural variation in testosterone that occurs during later fetal development. Sex-specific epi-marks stop girl fetuses from being masculinized when they experience atypically high testosterone, and vice versa for boy fetuses. Different epi-marks protect different sex-specific traits from being masculinized or feminized, e.g., some affect the genitals, others sexual identity, and yet others affect sexual partner preference. However, when these epi-marks are transmitted across generations from fathers to daughters or mothers to sons, they may cause reversed effects, such as the feminization of some traits in sons, such as sexual preference, and similarly a partial masculinization of daughters.
The study solves the evolutionary riddle of homosexuality, finding that "sexually antagonistic" epi-marks, which normally protect parents from natural variation in sex hormone levels during fetal development, sometimes carryover across generations and cause homosexuality in opposite-sex offspring, explained the study's co-author Sergey Gavrilets, Ph.D., NIMBioS' associate director for scientific activities and a professor at the University of Tennessee-Knoxville. The mathematical modelingdemonstrates that genes coding for these epi-marks can easily spread in the population because they always increase the fitness of the parent but only rarely escape erasure and reduce fitness in offspring.
"Transmission of sexually antagonistic epi-marks between generations is the most plausible evolutionary mechanism of the phenomenon of human homosexuality," said Dr. Gavrilets.
The new study is not the first to delineate the potential impact of epigenetics on sexual orientation and preference. In 2001, writing in Neuroendocrinology Letters, Günter Dörner, M.D., from the Berlin, Germany-based Humboldt University Medical School, and colleagues, published an article entitled “Genetic and Epigenetic Effects on Sexual Brain Organization Mediated by Sex Hormones.”
The study concluded as follows: “Most of all, our findings support the theory inaugurated in the 1970s that sex hormone activities in pre- and early postnatal life, which can be altered by genetic as well as by epigenetic effects, are able to program sexual brain organization and hence sexual orientation, gender role behavior, and gender identity as well as gonadal functions throughout life.”

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"Ethics" is simply a last-gasp attempt by deist conservatives and
orthodox dogmatics to keep humanity in ignorance and obscurantism,
through the well tried fermentation of fear, the fear of science and
new technologies.
 
There is nothing glorious about what our ancestors call history, 
it is simply a succession of mistakes, intolerances and violations.
 
On the contrary, let us embrace Science and the new technologies
unfettered, for it is these which will liberate mankind from the
myth of god, and free us from our age old fears, from disease,
death and the sweat of labour.
 
Rael
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