วันอังคารที่ 5 มีนาคม พ.ศ. 2556

[rael-science] Next-Gen Treatment: Viruses To Kill Prostate Cancer‏

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Source: http://www.medicaldaily.com/articles/14147/20130226/newcastle-virus-prostate-cancer-enzyme-cells.htm

Next-Gen Treatment: Viruses To Kill Prostate Cancer

By editing a virus that is known to kill tumor cells, researchers have shown that the new virus can selectively kill prostate cancer cells.

Feb 26, 2013

A modified virus that only targets cancerous cells for death and leaves healthy cells alone is ready for trials in animals and possibly Phase I safety trials in people.


















Researchers used a virus called Newcastle Virus, that infects chickens, but does not affect humans. But what it does in humans is home in on tumor cells as was seen in a few human trials. But such trials were ineffective because of lack of enough virus or failure to penetrate solid tumors.
The researchers got around this limitation by genetically engineering a protein that the virus uses to fuse to a cell to only interact with a prostate specific enzyme. This way the virus now seeks out and only infects prostate cancer cells. They now call the virus "Retargeted Newcastle Virus."
Retargeted Newcastle disease virus has major potential advantages over other cancer therapies, says Subbiah Elankumaran in a press release. First, its specificity for prostate cancer cells means it would not attack normal cells, thereby avoiding the various unpleasant side effects of conventional chemotherapies. In previous clinical trials, even with extremely large doses of naturally occurring strains, "only mild flu-like symptoms were seen in cancer patients," says Elankumaran. Second, it would provide a new treatment for hormone-refractory patients, without the side effects of testosterone suppression that result from hormonal treatments.
One in six men will be diagnosed with prostate cancer and one in 36 men will die of the disease. 
The report in the journal Virology can be found here.


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"Ethics" is simply a last-gasp attempt by deist conservatives and
orthodox dogmatics to keep humanity in ignorance and obscurantism,
through the well tried fermentation of fear, the fear of science and
new technologies.
 
There is nothing glorious about what our ancestors call history, 
it is simply a succession of mistakes, intolerances and violations.
 
On the contrary, let us embrace Science and the new technologies
unfettered, for it is these which will liberate mankind from the
myth of god, and free us from our age old fears, from disease,
death and the sweat of labour.
 
Rael
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